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Otilonium bromide
- Parent CAS: 105360-89-2
- Soluble in DMSO
- MF: C29H43BrN2O4
- MW: 563.57
Description
Otilonium bromide is a Ca2+ channel blocker. The main action consists in the blockade of Ca2+ entry through L-type Ca2+ channels and interference with intracytoplasmatic Ca2+ mobilization necessary for smooth muscle cell (SMC) contraction, thus preventing excessive bowel contractions and abdominal cramps. Further, Otilonium bromide blocks the T-type Ca2+ channels and interferes with the muscarinic responses; it interacts, directly or indirectly, with the tachykinin receptors on SMC and on primary afferent neurons whose combined effects may result in the reduction of motility and abdominal pain.
More Information
| Parent CAS No. | 105360-89-2 |
|---|---|
| Chemical Name | N,N-Diethyl-N-methyl-2-(4-(2-(octyloxy)benzamido)benzoyloxy)ethanaminium bromide |
| SMILES | C1C=C(C(NC2C=CC(C(OCC[N+](C)(CC)CC)=O)=CC=2)=O)C(OCCCCCCCC)=CC=1.[Br-] |
| MFCD | MFCD00211142 |
| InChi | InChI=1S/C29H42N2O4.BrH/c1-5-8-9-10-11-14-22-34-27-16-13-12-15-26(27)28(32)30-25-19-17-24(18-20-25)29(33)35-23-21-31(4,6-2)7-3;/h12-13,15-20H,5-11,14,21-23H2,1-4H3;1H |
| InChiKey | VWZPIJGXYWHBOW-UHFFFAOYSA-N |
| CID | 72092 |
| Short Description | Ca channel blocker |
References
- L Gandia et al. Otilonium: a potent blocker of neuronal nicotinic ACh receptors in bovine chromaffin cells. Br J Pharmacol. 1996 Feb;117(3):463-470.
- M Ghelardoni et al. Quaternary salts of substituted 2-aminoethyl N-benzoylaminobenzoate. New class of smooth muscle relaxant agents. J. Med. Chem. 1973, 16, 9, 1063–1065
- S Evangelista et al. Otilonium Bromide: A Drug with a Complex Mechanism of Action. Curr Pharm Des. 2018;24(16):1772-1779.
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