Otilonium bromide is a Ca2+ channel blocker. The main action consists in the blockade of Ca2+ entry through L-type Ca2+ channels and interference with intracytoplasmatic Ca2+ mobilization necessary for smooth muscle cell (SMC) contraction, thus preventing excessive bowel contractions and abdominal cramps. Further, Otilonium bromide blocks the T-type Ca2+ channels and interferes with the muscarinic responses; it interacts, directly or indirectly, with the tachykinin receptors on SMC and on primary afferent neurons whose combined effects may result in the reduction of motility and abdominal pain.

KEYWORDS: Otilonium bromide | supplier | Ca channel blocker | CAS [26095-59-0] | [105360-89-2] | Calcium | Non Selective | Blocker | Ion Channels | Spasmolytic | IBS | Irritable Bowel Syndrome