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JTP 0819958
- HOIPIN-1
- Parent CAS: 2439183-22-7
- Soluble in water and DMSO
- MF: C17H13NaO4
- MW: 304.27
Description
JTP 0819958 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor. JTP 0819958 exhibited IC50 values of 4.4, 3.5 and 3.7 μM for inhibition of linear polyubiquitination activity by the HOIL-1L/HOIP complex, the HOIL-1L/HOIP/SHARPIN complex and the HOIP/SHARPIN complex, respectively.
The prodrug JTP 1048196 is also available as Axon 2947.
More Information
| Parent CAS No. | 2439183-22-7 |
|---|---|
| Chemical Name | Sodium (E)-2-(3-(2-methoxyphenyl)-3-oxoprop-1-enyl)benzoate |
| SMILES | C1C=C(C(=O)[O-])C(/C=C/C(=O)C2C=CC=CC=2OC)=CC=1.[Na+] |
| MFCD | N.A. |
| InChi | InChI=1S/C17H14O4.Na/c1-21-16-9-5-4-8-14(16)15(18)11-10-12-6-2-3-7-13(12)17(19)20;/h2-11H,1H3,(H,19,20);/q;+1/p-1/b11-10+; |
| InChiKey | JCKWBPCGGVUJEV-ASTDGNLGSA-M |
| CID | 137628274 |
| Short Description | LUBAC inhibitor |
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