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OSS-128167
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C19H14N2O6
- MW: 366.32
Description
OSS-128167 is a selective inhibitor of the NAD-dependent deacylase SIRT6 with an IC50 value of 89 µM. SIRT6 regulates histone deacetylation, DNA repair, glucose metabolism, inflammatory transcription and cellular stress responses.
OSS-128167 is used to examine the consequences of pharmacological SIRT6 inhibition in metabolic, inflammatory and cardiovascular systems. Because its biochemical potency is in the high-micromolar range, cellular experiments should include concentration-matched controls and direct SIRT6 substrate-acetylation readouts.
Key Features
- Selective SIRT6 inhibitor
- IC50: 89 µM
- Modulates SIRT6-dependent chromatin and metabolic pathways
- Useful for loss-of-function pharmacology
Applications
- SIRT6 enzymology
- Histone-acetylation studies
- Glucose-metabolism research
- DNA-repair and stress-response assays
- Inflammation and cardiovascular models
More Information
| Parent CAS No. | 887686-02-4 |
|---|---|
| Chemical Name | 5-(3-(Furan-2-carboxamido)benzamido)-2-hydroxybenzoic acid |
| SMILES | C1C=CC(C(=O)NC2C=C(C(=O)O)C(O)=CC=2)=CC=1NC(=O)C1OC=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H14N2O6/c22-15-7-6-13(10-14(15)19(25)26)20-17(23)11-3-1-4-12(9-11)21-18(24)16-5-2-8-27-16/h1-10,22H,(H,20,23)(H,21,24)(H,25,26) |
| InChiKey | HTJWLEGCECXGSQ-UHFFFAOYSA-N |
| CID | 6496840 |
| Short Description | SIRT 6 inhibitor |
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