SAR405838 - MI-77301

Based on 12 reference(s) in Google Scholar 8 10 12

Axon 2741

CAS [1303607-60-4]

MF C29H34Cl2FN3O3
MW 562.50

  • Purity: 98%
  • Optical purity: Optically pure
  • Soluble in DMSO



SAR405838 is an inhibitor of the MDM2-p53 interaction with high specificity over other proteins (Ki value of 0.88 nM). SAR405838 effectively activates wild-type p53 in vitro and in xenograft tumor tissue of leukemia and solid tumors, leading to p53-dependent cell-cycle arrest and/or apoptosis. At well-tolerated dose schedules, SAR405838 achieves either durable tumor regression or complete tumor growth inhibition in mouse xenograft models of SJSA-1 osteosarcoma, RS4;11 acute leukemia, LNCaP prostate cancer, and HCT-116 colon cancer.

KEYWORDS: SAR405838 | supplier | MDM2 inhibitor | MI-77301 | SAR 405838 | SAR-405838 | MI 77301 | MI77301 | CAS [1303607-60-4] | p53 | HDM-MDM | Inhibitor | Enzymes | Apoptosis

Size Unit Price Stock
5 mg €125.00 In Stock
25 mg €475.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €200.00 In Stock
2 x 25 mg €760.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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