Cenicriviroc - TBR 652 | TAK 652 | CVC

Based on 95 publications in PubMed 10 10 95

Axon 2665

CAS [497223-25-3]

MF C41H52N4O4S
MW 696.94

Purity: 99%
Soluble in DMSO

Cenicriviroc

Description

Oral CCR5-antagonist for treatment of HIV infection (IC50 value 0.043 nM for the wild-type virus (KKWT) was in PBMCs) that also has activity against the inflammatory chemokine CCR2.

KEYWORDS: Cenicriviroc | supplier | CCR5 antagonist | TBR 652 | TAK 652 | CVC | TBR652 | TAK652 | CAS [497223-25-3] | [497223-28-6] | Chemokine | GPCR | CCR2 | HIV-1 | viral replication | antiretroviral | inflammatory | gp120

M Baba et al. TAK-652 inhibits CCR5-mediated human immunodeficiency virus type 1 infection in vitro and has favorable pharmacokinetics in humans. Antimicrob Agents Chemother. 2005 Nov;49(11):4584-91.

M Baba et al. Isolation and Characterization of Human Immunodeficiency Virus Type 1 Resistant to the Small-Molecule CCR5 Antagonist TAK-652. Antimicrob Agents Chemother. 2007 Feb; 51(2): 707–715.

TJ Henrich et al. HIV-1 entry inhibitors: recent development and clinical use. Curr Opin Virol. 2013 Feb;3(1):51-7.

M Seto et al. Highly potent and orally active CCR5 antagonists as anti-HIV-1 agents: synthesis and biological activities of 1-benzazocine derivatives containing a sulfoxide moiety. J Med Chem. 2006 Mar 23;49(6):2037-48.

Cell Signaling & Oncology Immunology Pain & Inflammation A1 Chemokine Antiviral agents Infectious Disease

Oral CCR5-antagonist for treatment of HIV infection

Chemical name

(S)-8-(4-(2-butoxyethoxy)phenyl)-1-isobutyl-N-(4-((1-propyl-1H-imidazol-5-yl)methylsulfinyl)phenyl)-1,2,3,4-tetrahydrobenzo[b]azocine-5-carboxamide

Parent CAS No.

[497223-25-3]

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Cenicriviroc - TBR 652 | TAK 652 | CVC

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Cenicriviroc - TBR 652 | TAK 652 | CVC

Description

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Parent CAS No.

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