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Cenicriviroc
- TBR 652 - TAK 652 - CVC
- Soluble in DMSO
- MF: C41H52N4O4S
- MW: 696.94
Description
Oral CCR5-antagonist for treatment of HIV infection (IC50 value 0.043 nM for the wild-type virus (KKWT) was in PBMCs) that also has activity against the inflammatory chemokine CCR2.
More Information
| Parent CAS No. | 497223-25-3 |
|---|---|
| Chemical Name | (S)-8-(4-(2-butoxyethoxy)phenyl)-1-isobutyl-N-(4-((1-propyl-1H-imidazol-5-yl)methylsulfinyl)phenyl)-1,2,3,4-tetrahydrobenzo[b]azocine-5-carboxamide |
| MFCD | N.A. |
| Short Description | CCR5 antagonist |
References
- M Baba et al. TAK-652 inhibits CCR5-mediated human immunodeficiency virus type 1 infection in vitro and has favorable pharmacokinetics in humans. Antimicrob Agents Chemother. 2005 Nov;49(11):4584-91.
- M Baba et al. Isolation and Characterization of Human Immunodeficiency Virus Type 1 Resistant to the Small-Molecule CCR5 Antagonist TAK-652. Antimicrob Agents Chemother. 2007 Feb; 51(2): 707–715.
- TJ Henrich et al. HIV-1 entry inhibitors: recent development and clinical use. Curr Opin Virol. 2013 Feb;3(1):51-7.
- M Seto et al. Highly potent and orally active CCR5 antagonists as anti-HIV-1 agents: synthesis and biological activities of 1-benzazocine derivatives containing a sulfoxide moiety. J Med Chem. 2006 Mar 23;49(6):2037-48.
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