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AZD2098
- Soluble in DMSO
- MF: C11H9Cl2N3O3S
- MW: 334.18
Description
AZD2098 is a potent, selective and bioavailable antagonist of the chemokine receptor CCR4, with a reported pIC50 value of 7.8. It blocks receptor activation by CCR4 ligands such as CCL17 and CCL22 and thereby suppresses downstream chemotactic signaling.
CCR4 is expressed on subsets of T helper cells, regulatory T cells and other leukocytes. AZD2098 is used to investigate CCR4-dependent immune-cell migration, airway inflammation and recruitment of type 2 inflammatory lymphocytes.
Key Features
- Potent CCR4 receptor antagonist
- pIC50: 7.8
- Selective and bioavailable
- Blocks chemokine-driven cell migration
Applications
- CCR4 receptor pharmacology
- CCL17 and CCL22 signaling studies
- Leukocyte chemotaxis assays
- Airway inflammation models
- T-cell trafficking research
More Information
| Parent CAS No. | 566203-88-1 |
|---|---|
| Chemical Name | 2,3-Dichloro-N-(3-methoxypyrazin-2-yl)benzenesulfonamide |
| SMILES | C1C=C(S(NC2C(OC)=NC=CN=2)(=O)=O)C(Cl)=C(Cl)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C11H9Cl2N3O3S/c1-19-11-10(14-5-6-15-11)16-20(17,18)8-4-2-3-7(12)9(8)13/h2-6H,1H3,(H,14,16) |
| InChiKey | FLSMVCMSUNISFK-UHFFFAOYSA-N |
| CID | 10308720 |
| Short Description | CCR4 antagonist |
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