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BX 471
- Optical Purity: Optically pure
- Soluble in DMSO and EtOH
- MF: C21H24ClFN4O3
- MW: 434.89
Description
BX 471 is a potent, orally active and selective CCR1 chemokine receptor antagonist. It blocks CCR1-mediated chemokine signaling involved in leukocyte recruitment and inflammatory cell trafficking.
CCR1 contributes to monocyte, neutrophil and T-cell migration in inflammatory and autoimmune disease models. BX 471 is useful for studying chemokine receptor pharmacology, leukocyte trafficking and tissue inflammation.
Key Features
- Selective CCR1 antagonist
- Orally active pharmacological profile
- Blocks chemokine-driven leukocyte recruitment
- Relevant to inflammatory and autoimmune disease models
Applications
- CCR1 receptor assays
- Chemotaxis and leukocyte migration studies
- Inflammation model research
- Chemokine receptor antagonist profiling
More Information
| Parent CAS No. | 217645-70-0 |
|---|---|
| Chemical Name | (R)-1-(5-chloro-2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)phenyl)urea |
| SMILES | N(C1=CC(Cl)=CC=C1OCC(N1CCN(CC2=CC=C(F)C=C2)C[C@H]1C)=O)C(N)=O |&1:24,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C21H24ClFN4O3/c1-14-11-26(12-15-2-5-17(23)6-3-15)8-9-27(14)20(28)13-30-19-7-4-16(22)10-18(19)25-21(24)29/h2-7,10,14H,8-9,11-13H2,1H3,(H3,24,25,29)/t14-/m1/s1 |
| InChiKey | XQYASZNUFDVMFH-CQSZACIVSA-N |
| CID | 512282 |
| Short Description | CCR1 antagonist |
References
- M Liang et al. Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1. J. Biol. Chem. 2000, 275(25), 19000.
- N Vaidehi et al. Predictions of CCR1 chemokine receptor structure and BX 471 antagonist binding followed by experimental validation. J. Biol. Chem. 2006, 281(37), 27613-27620.
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