Bulk Inquiry
SC 79
- Soluble in DMSO
- MF: C17H17ClN2O5
- MW: 364.78
Description
Unique specific activator of cytosolic Akt (PKB) with the potential to recapitulate the primary cellular function of Akt signaling in a hippocampal neuronal culture system and a mouse model for ischemic stroke, resulting in augmented neuronal survival. Paradoxically, SC 79 suppressed PH-Akt-GFP plasma membrane translocation.
Close analogue of HA 14-1 (Axon 2007), a Bcl-2 antagonist (IC50 value 9 µM).
More Information
| Parent CAS No. | 305834-79-1 |
|---|---|
| Chemical Name | ethyl 2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate |
| SMILES | C1(N)OC2=CC=C(Cl)C=C2C(C(C#N)C(OCC)=O)C=1C(OCC)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C17H17ClN2O5/c1-3-23-16(21)11(8-19)13-10-7-9(18)5-6-12(10)25-15(20)14(13)17(22)24-4-2/h5-7,11,13H,3-4,20H2,1-2H3 |
| InChiKey | DXVKFBGVVRSOLI-UHFFFAOYSA-N |
| CID | 2810830 |
| Short Description | Akt activator |
References
- H Jo et al. Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10581-6.
- J Skommen et al. HA14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells. Leukemia Res. 2006, 30(3), 322–331.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1239 | Deguelin |
From $121.00 |
| 1602 | PF 4708671 |
From $121.00 |
| 1663 | Perifosine |
From $93.50 |
| 1684 | MK 2206 dihydrochloride |
From $88.00 |
| 1685 | YS 49 |
From $148.50 |
| 1729 | GSK 690693 |
From $143.00 |
| 1790 | SC 66 |
From $77.00 |
| 1859 | AZD5363 dihydrochloride |
From $99.00 |
| 1870 | PHT 427 |
From $82.50 |
| 1903 | DG2 |
From $104.50 |
| 2007 | HA 14-1 |
From $82.50 |
| 2166 | AT 13148 dihydrochloride |
From $77.00 |
| 2460 | GSK 2110183 hydrochloride |
From $115.50 |
| 3343 | ML-9 hydrochloride |
From $66.00 |
| 3850 | M2698 |
From Inquiry |
| 3958 | Uprosertib |
From Inquiry |
| 4037 | GDC-0068 |
From Inquiry |
Other Categories
Are you sure you would like to remove this item from the shopping cart?
This item is a part of the approved quote. Removing it will remove all quote items from the cart.