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LY 2584702 tosylate
- Parent CAS: 1082949-67-4
- Soluble in DMSO
- MF: C21H19F4N7.C7H8O3S
- MW: 617.62
Description
Oral, selective ATP-competitive inhibitor of p70 S6 kinase (S6K1; IC50 value 4 nM) with significant synergistic activity with Erlotinib (Axon 1128) and Everolimus (Axon 4149). LY2584702 is selective against 83 other kinases as determined by a ubiquitin kinase panel, and 45 cell surface markers as determined by a CEREP mini panel.
More Information
| Parent CAS No. | 1082949-67-4 |
|---|---|
| Chemical Name | 4-(4-(4-(4-Fluoro-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazol-2-yl)piperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine tosylate |
| SMILES | C1=NC(N2CCC(C3N(C)C=C(C4=CC=C(F)C(C(F)(F)F)=C4)N=3)CC2)=C2C=NNC2=N1.C1(C)C=CC(S(O)(=O)=O)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H19F4N7.C7H8O3S/c1-31-10-17(13-2-3-16(22)15(8-13)21(23,24)25)29-19(31)12-4-6-32(7-5-12)20-14-9-28-30-18(14)26-11-27-20;1-6-2-4-7(5-3-6)11(8,9)10/h2-3,8-12H,4-7H2,1H3,(H,26,27,28,30);2-5H,1H3,(H,8,9,10) |
| InChiKey | HDYUXDNMHBQKAU-UHFFFAOYSA-N |
| CID | 46205871 |
| Short Description | S6K1 inhibitor |
References
- A. Hollebecque et al. A phase Ib trial of LY2584702 tosylate, a p70 S6 inhibitor, in combination with erlotinib or everolimus in patients with solid tumours. Eur J Cancer. 2014 Mar;50(5):876-84.
- A. Tolcher et al. A phase I trial of LY2584702 tosylate, a p70 S6 kinase inhibitor, in patients with advanced solid tumours. Eur J Cancer. 2014 Mar;50(5):867-75.
- H Liu et al. Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia. Cell Reports 2017 Feb. 18(9):2088–2095.
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