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UNC 0379

Axon 2418
CAS:  1620401-82-2
Purity:  98%
  • Soluble in DMSO
  • MF:  C23H35N5O2
  • MW:  413.56

Description

Substrate competitive inhibitor of the H4K20 HMTase SETD8 (IC50 value 7.3 µM) with selectivity over 15 other methyltransferases including G9a and GLP. MOA studies revealed that UNC0379 is noncompetitive with the cofactor S-adenosyl-Lmethionine (SAM).

More Information

Certificate of Analysis

Material Safety Data Sheet

Parent CAS No. 1620401-82-2
Chemical Name 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine
SMILES N1=C2C(C=C(OC)C(OC)=C2)=C(NCCCCCN2CCCC2)N=C1N1CCCC1
MFCD N.A.
InChi InChI=1S/C23H35N5O2/c1-29-20-16-18-19(17-21(20)30-2)25-23(28-14-8-9-15-28)26-22(18)24-10-4-3-5-11-27-12-6-7-13-27/h16-17H,3-15H2,1-2H3,(H,24,25,26)
InChiKey WEXCGGWTIDNVNT-UHFFFAOYSA-N
CID 78357767
Short Description SETD8 HMTase inhibitor

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