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A-196
Axon 2705
CAS:
1982372-88-2
Purity:
99%
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C18H16Cl2N4
- MW: 359.25
Description
A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 ((IC50 values of 25 and 144 nM, respectively). In cells, A-196 induced a global decrease in H4K20me2 and H4K20me3 and a concomitant increase in H4K20me1. A-196 inhibited 53BP1 foci formation upon ionizing radiation and reduced NHEJ-mediated DNA-break repair but did not affect homology-directed repair.
More Information
| Parent CAS No. | 1982372-88-2 |
|---|---|
| Chemical Name | 6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine |
| SMILES | C1C(C2C3C=C(Cl)C(Cl)=CC=3C(NC3CCCC3)=NN=2)=CC=NC=1 |
| MFCD | MFCD29924807 |
| InChi | InChI=1S/C18H16Cl2N4/c19-15-9-13-14(10-16(15)20)18(22-12-3-1-2-4-12)24-23-17(13)11-5-7-21-8-6-11/h5-10,12H,1-4H2,(H,22,24) |
| InChiKey | ABGOSOMRWSYAOB-UHFFFAOYSA-N |
| CID | 117072548 |
| Short Description | SUV4-20 inhibitor |
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