Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2391

CAS [1448009-94-6]

MF C16H12O3
MW 252.26

  • Purity: 99%
  • Soluble in DMSO



TOPO IIα inhibitor with broad-spectrum in vitro antitumor effects (IC50 values 4.3 µM, 11.5 µM, and 4.6 µM for inhibition of proliferation of breast cancer MDA-MB-231, human lung cancer A549 and human cervical cancer HeLa cell lines, respectively). CS1 functions as a Topo II poison to stabilize Topo II/DNA complex, which leads to DNA damage, cell cycle arrest at G2/M phase and apoptosis, and is 6–10-fold less cytotoxic against HL7702 and HUVEC cells compared with etoposide.
Size Unit Price Stock
10 mg €135.00 In Stock
50 mg €505.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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