AK 7

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2270

CAS [420831-40-9]

MF C19H21BrN2O3S
MW 437.35

  • Purity: 100%
  • Soluble in DMSO

AK 7


Potent, brain-permeable and selective inhibitor of SIRT2 (IC50 values >50 μM, 15.5 μM, and >50 μM for SIRT1, SIRT2, and SIRT3 respectively. Treatment with AK 7 showed a SIRT2-dependent nucleo-cytoplasmic trafficking in primary striatal neurons of the master regulator of cholesterol biosynthesis, SREBP-2, and resulted in protection of neurons in an in vitro model of Huntington's disease (HD).
AK 7 is slightly less potent in vitro than its analogue AK 1 (Axon 2269).

Size Unit Price Stock
10 mg €90.00 In Stock
50 mg €340.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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