AK 1

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2269

CAS [330461-64-8]

MF C19H21N3O5S
MW 403.45

  • Purity: 100%
  • Soluble in DMSO

AK 1


Potent inhibitor of SIRT with good selectivity for SIRT2 over SIRT1 and SIRT3 (IC50 values >50 μM, 12.5 μM, and >50 μM for SIRT1, SIRT2, and SIRT3 respectively. Short-term treatment with AK 1 produced large statistically significant changes in RNA expression in untransduced, Htt171-18Q- and Htt171-82Q-expressing neurons and confirm the hypothesis that AK 1-mediated neuroprotection is correlated with the negative regulation of sterol biosynthesis.
AK 1 is among the first brain-permeable SIRT2 inhibitors that mediate neuroprotective reduction of cholesterol biosynthesis in an in vitro Huntington’s disease model. More potent in vitro than its analogue AK 7 (Axon 2270).

Size Unit Price Stock
10 mg €90.00 In Stock
50 mg €340.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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