GSK 1838705A - GSK 1838705

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2267

CAS [1116235-97-2]

MF C27H29FN8O3
MW 532.57

  • Purity: 99%
  • Soluble in DMSO

GSK 1838705A


Potent and selective insulin-like growth factor-1 receptor (IGF-IR) and insulin receptor (IR) kinase inhibitor with additional affinity for anaplastic lymphoma kinase (ALK) with IC50 values of 2.0 nM, 1.6 nM, and 0.6 nM, for IGF1R, IR, and ALK respectively, and >800-fold selectivity over related kinases, including RSK1, JNK3, and B-Raf V600EGSK 1838705A inhibits the proliferation of cancer cell lines, comprises the growth of human tumor xenografts in vivo, and causes complete regression of ALK-dependent tumors in vivo at well-tolerated doses.
Size Unit Price Stock
5 mg €110.00 In Stock
25 mg €380.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €170.00 In Stock
2 x 25 mg €620.00 In Stock
Need more? Bulk Inquiry

The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

Please wait...