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NT 157
Axon 2238
CAS:
1384426-12-3
Purity:
99%
- Soluble in DMSO
- MF: C16H14BrNO5S
- MW: 412.26
Description
Unique allosteric inhibitor of IGF1R. NT 157 promotes ERK-MAPK dependent inhibitory Ser-phosphorylation and degradation of insulin receptor substrate 1 and 2 (IRS1/2) by shifting IGF1R complexation from IRS1/2 to Shc, which results in long-term inhibition of IGF1R signaling and powerful inhibition of tumor cell growth.
More Information
| Parent CAS No. | 1384426-12-3 |
|---|---|
| Chemical Name | (E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide |
| SMILES | C(=S)(NCC1=CC(O)=C(O)C(O)=C1)/C=C/C1=CC(O)=C(O)C(Br)=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C16H14BrNO5S/c17-10-3-8(4-11(19)15(10)22)1-2-14(24)18-7-9-5-12(20)16(23)13(21)6-9/h1-6,19-23H,7H2,(H,18,24)/b2-1+ |
| InChiKey | NIPUPOUEGOSAAO-OWOJBTEDSA-N |
| CID | 135398520 |
| Short Description | Allosteric inhibitor of IGF1R |
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