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Alectinib
- CH5424802
- Moderately soluble in DMSO
- MF: C30H34N4O2
- MW: 482.62
Description
Alectinib (CH5424802) is a potent, orally available and selective anaplastic lymphoma kinase (ALK) inhibitor capable of blocking resistant ALK gatekeeper mutants.
ALK rearrangements and activating mutations drive kinase signaling in several cancer models, especially ALK fusion-positive lung cancer. Alectinib is used to study ALK pathway dependence, mutant kinase resistance and targeted oncology pharmacology.
Key Features
- Selective ALK inhibitor
- Active against resistant ALK gatekeeper mutant signaling
- Orally available oncology-relevant kinase inhibitor
- Clinically relevant reference for ALK-positive tumor research
Applications
- ALK fusion and mutant kinase studies
- NSCLC and targeted oncology models
- RTK phosphorylation and pathway inhibition assays
- Kinase resistance mechanism research
More Information
| Parent CAS No. | 1256580-46-7 |
|---|---|
| Chemical Name | 9-ethyl-6,6-dimethyl-8-(4-morpholinopiperidin-1-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile |
| SMILES | N1C2=C(C=CC(C#N)=C2)C2=C1C(C)(C)C1=CC(N3CCC(N4CCOCC4)CC3)=C(CC)C=C1C2=O |
| MFCD | MFCD19440988 |
| InChi | InChI=1S/C30H34N4O2/c1-4-20-16-23-24(17-26(20)34-9-7-21(8-10-34)33-11-13-36-14-12-33)30(2,3)29-27(28(23)35)22-6-5-19(18-31)15-25(22)32-29/h5-6,15-17,21,32H,4,7-14H2,1-3H3 |
| InChiKey | KDGFLJKFZUIJMX-UHFFFAOYSA-N |
| CID | 49806720 |
| Short Description | ALK inhibitor |
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