LGX818
- Encorafenib - NVP-LGX818
Axon 4146
CAS:
1269440-17-6
- Optical Purity: 99% e.e.
- Soluble in DMSO
- MF: C22H27ClFN7O4S
- MW: 540.01
Description
LGX818 is a selective ATP-competitive RAF kinase inhibitor of B-RafV600E mutant melanoma cell proliferation (EC50 = 4 nM) with little activity against wild-type B-Raf or a panel of 100 other kinases (IC50s = 900 nM). At oral doses of 6 mg/kg in human melanoma xenograft models, LGX818 was shown to decrease phosphorylation of the B-Raf substrate MEK.
More Information
| Parent CAS No. | 1269440-17-6 |
|---|---|
| Chemical Name | (S)-Methyl 1-(4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-ylamino)propan-2-ylcarbamate |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1(F)C(C2=NN(C(C)C)C=C2C2N=C(NC[C@H](C)NC(=O)OC)N=CC=2)=CC(Cl)=CC=1NS(=O)(=O)C |&1:16,r| |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | RAF inhibitor |
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