TAK-632
- Soluble in DMSO
- MF: C27H18F4N4O3S
- MW: 554.52
Description
TAK-632 is a potent and selective pan-RAF inhibitor targeting B-RAF V600E (IC50 = 2.4 nM), C-RAF (IC50 1.4 nM) and VEGFR (IC50 = 160 nM), displaying significant cellular activity against mutated BRAF and mutated NRAS cancer cell lines.
More Information
| Parent CAS No. | 1228591-30-7 |
|---|---|
| Chemical Name | N-(7-Cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C12N=C(NC(=O)C3CC3)SC=1C(C#N)=C(OC1C=CC(F)=C(NC(CC3C=C(C(F)(F)F)C=CC=3)=O)C=1)C=C2 |
| MFCD | N.A. |
| InChi | InChI=1S/C27H18F4N4O3S/c28-19-7-6-17(12-21(19)33-23(36)11-14-2-1-3-16(10-14)27(29,30)31)38-22-9-8-20-24(18(22)13-32)39-26(34-20)35-25(37)15-4-5-15/h1-3,6-10,12,15H,4-5,11H2,(H,33,36)(H,34,35,37) |
| InChiKey | OJFKUJDRGJSAQB-UHFFFAOYSA-N |
| CID | 46209401 |
| Short Description | RAF inhibitor |
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