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PLX 4720
- Soluble in DMSO
- MF: C17H14ClF2N3O3S
- MW: 413.83
Description
PLX 4720 is a selective ATP-competitive inhibitor of oncogenic BRAF, with preferential activity against the V600E mutant. By suppressing mutant BRAF kinase activity, it inhibits downstream MEK–ERK signaling in BRAF-driven cells.
PLX 4720 is widely used to investigate MAPK pathway dependence, adaptive resistance and the context-dependent paradoxical activation of ERK signaling that can occur in cells with upstream RAS activity and wild-type RAF.
Key Features
- Selective inhibitor of BRAF V600E kinase activity
- Suppresses mutant BRAF-driven MEK–ERK signaling
- Useful for distinguishing mutant BRAF dependence from wild-type RAF signaling
- Supports studies of RAF-inhibitor resistance and paradoxical MAPK activation
Applications
- BRAF V600E and MAPK pathway research
- Melanoma and other BRAF-mutant cancer models
- Mechanisms of resistance to RAF inhibition
- RAS–RAF–MEK–ERK signaling studies
More Information
| Parent CAS No. | 918505-84-7 |
|---|---|
| Chemical Name | Propane-1-sulfonic acid [3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-amide |
| SMILES | C1(C(C(=O)C2C3=CC(Cl)=CN=C3NC=2)=C(F)C(=CC=1)NS(=O)(=O)CCC)F |
| MFCD | MFCD14635203 |
| InChi | InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22) |
| InChiKey | YZDJQTHVDDOVHR-UHFFFAOYSA-N |
| CID | 24180719 |
| Short Description | B-Raf inhibitor |
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