NSC 687852 - b-AP15

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2228

CAS [1009817-63-3]

MF C22H17N3O6
MW 419.39

  • Purity: 98%
  • Soluble in DMSO

NSC 687852

Description

Inhibitor of two 19S regulatory-particle–associated deubiquitinases (DUBs), ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) showing tumor growth inhibition in vivo. NSC 687852 shows IC50 values of 0.5 μM and 2.1 μM in cathepsin-dependent caspase-cleavage and in purified 19S proteasome Ub-AMC cleavage assays respectively.NSC 687852 induced tumor cell apoptosis that was insensitive to TP53 status and overexpression of the apoptosis inhibitor BCL2. UNC 687852 does not inhibit the non proteasomeal DUBs UCHL-1/3, USP-2/7/8 and BAP1.
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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