EPZ 6438 - Tazemetostat

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2227

CAS [1403254-99-8]

MF C34H44N4O4
MW 572.74

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO

EPZ 6438


Potent, selective, and orally bioavailable inhibitor of EZH2 enzymatic activity (IC50 values 2-38 nM in EZH2 assays). Induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells, and dose-dependently leads to regression of malignant rhabdoid tumors (MRTs) with correlative diminution of intratumoral trimethylation levels of H3K27, and prevention of tumor regrowth after dosing cessation.
Size Unit Price Stock
5 mg €90.00 In Stock
25 mg €300.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €140.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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