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EPZ 6438 - Tazemetostat

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2227

CAS [1403254-99-8]

MF C34H44N4O4
MW 572.74

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO

EPZ 6438

Description

Potent, selective, and orally bioavailable inhibitor of EZH2 enzymatic activity (IC50 values 2-38 nM in EZH2 assays). Induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells, and dose-dependently leads to regression of malignant rhabdoid tumors (MRTs) with correlative diminution of intratumoral trimethylation levels of H3K27, and prevention of tumor regrowth after dosing cessation.
Order
Size Unit Price Stock
5 mg €80.00 In Stock
25 mg €240.00 In Stock
Special Offers
Size Unit Price Stock
2 x 5 mg €120.00 In Stock
2 x 25 mg €360.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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