Bulk Inquiry
MS1943 trifluoroacetate
- Parent CAS: 2225938-17-8
- Soluble in DMSO and EtOH
- MF: C42H54N8O3.2CF3CO2H
- MW: 946.98
Description
MS1943 trifluoroacetate is a first-in-class EZH2 selective degrader that effectively reduces EZH2 levels in cells. MS1943 has a profound cytotoxic effect in multiple TNBC cells, while sparing normal cells, and is efficacious in vivo, suggesting that pharmacologic degradation of EZH2 can be advantageous for treating the cancers that are dependent on EZH2.
More Information
| Parent CAS No. | 2225938-17-8 |
|---|---|
| Chemical Name | 6-[6-[4-[2-[[2-(1-Adamantyl)acetyl]amino]ethyl]piperazin-1-yl]pyridin-3-yl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-propan-2-ylindazole-4-carboxamide trifluoroacetate |
| SMILES | C1C2CC3(CC(NCCN4CCN(C5C=CC(C6C=C(C(NCC7C(=O)NC(C)=CC=7C)=O)C7C=NN(C(C)C)C=7C=6)=CN=5)CC4)=O)CC1CC(C3)C2.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C42H54N8O3.2C2HF3O2/c1-26(2)50-37-18-33(17-34(36(37)25-46-50)40(52)45-24-35-27(3)13-28(4)47-41(35)53)32-5-6-38(44-23-32)49-11-9-48(10-12-49)8-7-43-39(51)22-42-19-29-14-30(20-42)16-31(15-29)21-42;2*3-2(4,5)1(6)7/h5-6,13,17-18,23,25-26,29-31H,7-12,14-16,19-22,24H2,1-4H3,(H,43,51)(H,45,52)(H,47,53);2*(H,6,7) |
| InChiKey | XFGDQQYQRXIWOI-UHFFFAOYSA-N |
| CID | 139211327 |
| Short Description | EZH2 degrader |
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