Multi-affinity drug. Targets Carbonic Anhydrases, FUT7, P4H, HATs, among many others in an inhibitory modus. Gallic acid is cytotoxic to cancer cells and has anti-inflammatory and antioxidative effects. Gallic acid was found to inhibit the histone acetyltransferase activity of several HATs (IC50 values: 14, 24, 25 and 34 μM for p300, CBP, Tip60 and PCAF respectively). In particular, it inhibited p300/CBP-dependent HAT activities uncompetitively, while being devoid of activity towards other epigenetic enzymes including SIRT1, HDAC, and HMTase. In A549 lung cancer cells, Gallic acid inhibited the acetylation of p65, leading to the downregulation of NF-κB activation in response to diverse inflammatory signals.Gallic acid is also known to inhibit HIV-1 infections through inhibition of HIV-1 reverse transcriptase activity in Lagerstroemia speciosa L.