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AZD1080
- Soluble in DMSO
- MF: C19H18N4O2
- MW: 334.37
Description
More Information
| Parent CAS No. | 612487-72-6 |
|---|---|
| Chemical Name | 2-Hydroxy-3-(5-(morpholinomethyl)pyridin-2-yl)-1H-indole-5-carbonitrile |
| SMILES | N1C2=C(C=C(C#N)C=C2)C(C2=NC=C(CN3CCOCC3)C=C2)=C1O |
| MFCD | N.A. |
| InChi | InChI=1S/C19H18N4O2/c20-10-13-1-3-16-15(9-13)18(19(24)22-16)17-4-2-14(11-21-17)12-23-5-7-25-8-6-23/h1-4,9,11,22,24H,5-8,12H2 |
| InChiKey | BLTVBQXJFVRPFK-UHFFFAOYSA-N |
| CID | 135564570 |
| Short Description | GSK-3 inhibitor |
References
- B Georgievska et al. AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans. J Neurochem. 2013, 125, 446-456.
- H Eldar-Finkelman et al. GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS. Front. Mol. Neurosci. 2011, 4, 32..
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