CCT 031374 hydrobromide

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2161

CAS [1219184-91-4]

MF C23H19N3O.HBr
MW 434.33

  • Purity: 98%
  • Soluble in DMSO

CCT 031374 hydrobromide

Description

Inhibitor of TCF-dependent transcription of genes of Wnt signaling pathway with in vivo activity in SW480 colon cancer cells (IC50 of 6.1 μM in a HEK293-based reporter cell line). CCT 031374 acts at the β-catenin level based on the observation that it blocked the nuclear β-catenin/transcription factor (TCF) transcription complex dependent transcription induced by a stabilized form of β-catenin, but not by a constitutively active TCF-VP16 fusion protein.
Inhibitor of TCF-dependent transcription of genes of Wnt signaling pathway

Chemical name

1-biphenyl-4-yl-2-(2,3-dihydro-benzo[d]imidazo[1,2-a]imidazol-9-yl)-ethanone hydrobromide

Parent CAS No.

[442535-46-8]

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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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