ADAMTS-5 inhibitor - Compound 12

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2083

CAS [929634-33-3]

MF C16H11ClF3N3OS3
MW 449.92

  • Purity: 100%
  • Soluble in 0.1N NaOH(aq) and DMSO

ADAMTS-5 inhibitor

Description

Inhibitor of ADAMTS-5 (A Disintegrin And Metalloproteinase with ThromboSpondin motifs 5 or aggrecanase-2; IC50 1.1 μM) with >40-fold functional selectivity over ADAMTS-4. ADAMTS-5 is involved in the catabolism of aggrecan and collagen in the articular cartilage matrix during Osteoarthritis (OA).
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5 mg €135.00 In Stock
25 mg €475.00 In Stock
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2 x 25 mg €720.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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