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NVP-BGJ398 phosphate
- BGJ 398 phosphate - Infigratinib phosphate
- Parent CAS: 872511-34-7
- Soluble in DMSO
- MF: C26H34Cl2N7O7P
- MW: 658.47
Description
Potent and selective inhibitor of fibroblast growth factor receptor (FGFR) tyrosine kinases 1, 2, 3 and 4 (with IC50 values of 0.9, 1.4, 1.0 and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4 respectively); it showed siginificant antitumor activity in RT112 bladder cancer xenografts models overexpressing wild-type FGFR3. Phosphate salt of Axon 1775
More Information
| Parent CAS No. | 872511-34-7 |
|---|---|
| Chemical Name | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)phenylamino)pyrimidin-4-yl)-1-methylurea phosphate |
| SMILES | N(C1C=C(NC2=CC=C(N3CCN(CC)CC3)C=C2)N=CN=1)(C)C(NC1=C(Cl)C(OC)=CC(OC)=C1Cl)=O.P(O)(O)(O)=O |
| MFCD | N.A. |
| InChi | InChI=1S/C26H31Cl2N7O3.H3O4P/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28;1-5(2,3)4/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31);(H3,1,2,3,4) |
| InChiKey | GUQNHCGYHLSITB-UHFFFAOYSA-N |
| CID | 56669626 |
| Short Description | FGFR inhibitor |
References
- V. Guagnano et al. Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the FGFR (...). J. Med. Chem. 2011, 54(20), 7066–7083.
- G Daniele et al. FGF Receptor Inhibitors: Role in Cancer Therapy. Curr. Oncol. Rep. 2012, 14(2), 111-119.
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