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AZD4547
- Fexagratinib - ADSK091
- Soluble in DMSO
- MF: C26H33N5O3
- MW: 463.57
Description
AZD4547 (Fexagratinib) is an orally available, potent and selective fibroblast growth factor receptor (FGFR) inhibitor targeting FGFR-driven signaling.
FGFR1, FGFR2 and FGFR3 alterations can drive tumor proliferation, survival, angiogenesis and resistance mechanisms. AZD4547 is used to study FGF pathway dependence and targeted inhibition in FGFR-altered oncology models.
Key Features
- Potent FGFR inhibitor
- Targets FGFR1, FGFR2 and FGFR3 signaling
- Orally available targeted oncology research compound
- Useful for FGFR alteration and pathway-dependence studies
Applications
- FGFR kinase pharmacology
- FGF pathway and phosphorylation assays
- FGFR-driven cancer cell models
- Targeted therapy resistance and biomarker research
More Information
| Parent CAS No. | 1035270-39-3 |
|---|---|
| Chemical Name | N-(5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3R,5S)-3,5-dimethylpiperazin-1-yl)benzamide, rel- |
| MFCD | MFCD20527275 |
| Short Description | FGFR inhibitor |
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