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NVP-BGJ398
- BGJ 398 - Infigratinib
- Soluble in DMSO
- MF: C26H31Cl2N7O3
- MW: 560.48
Description
Potent and selective inhibitor of fibroblast growth factor receptor (FGFR) tyrosine kinases 1, 2, 3 and 4 (with IC50 values of 0.9, 1.4, 1.0 and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4 respectively); it showed siginificant antitumor activity in RT112 bladder cancer xenografts models overexpressing wild-type FGFR3.
The phosphate salt of NVP-BGJ398 (Axon 1944) is available as well.
More Information
| Parent CAS No. | 872511-34-7 |
|---|---|
| Chemical Name | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)phenylamino)pyrimidin-4-yl)-1-methylurea |
| SMILES | N1(CC)CCN(C2C=CC(NC3N=CN=C(N(C)C(NC4C(Cl)=C(OC)C=C(OC)C=4Cl)=O)C=3)=CC=2)CC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31) |
| InChiKey | QADPYRIHXKWUSV-UHFFFAOYSA-N |
| CID | 53235510 |
| Short Description | FGFR inhibitor |
References
- V. Guagnano et al. Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the FGFR (...). J. Med. Chem. 2011, 54(20), 7066–7083.
- G Daniele et al. FGF Receptor Inhibitors: Role in Cancer Therapy. Curr. Oncol. Rep. 2012, 14(2), 111-119.
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