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BMS 345541
- Parent CAS: 445430-58-0
- Soluble in water and DMSO
- MF: C14H17N5.HCl
- MW: 291.78
Description
BMS 345541 is a cell-permeable, highly selective IκB kinase (IKK) inhibitor that binds an allosteric site and preferentially inhibits IKK-2 over IKK-1.
IKK activation is central to canonical NF-κB-dependent transcription in inflammatory and immune responses. BMS 345541 is used to study IKK isoform pharmacology and NF-κB pathway regulation.
Key Features
- Allosteric inhibitor of IKK kinase activity
- Approximately 10-fold more selective for IKK-2 over IKK-1
- Cell-permeable NF-κB pathway tool
- Blocks NF-κB-dependent transcription in reported models
Applications
- IKK/NF-κB signaling studies
- Inflammation and immune pathway assays
- Allosteric kinase inhibitor profiling
- Cytokine response and transcriptional regulation models
More Information
| Parent CAS No. | 445430-58-0 |
|---|---|
| Chemical Name | N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine hydrochloride |
| SMILES | C1(C)C=C2N3C(C)=CN=C3C(NCCN)=NC2=CC=1.Cl |
| MFCD | MFCD07784499 |
| InChi | InChI=1S/C14H17N5.ClH/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15;/h3-4,7-8H,5-6,15H2,1-2H3,(H,16,18);1H |
| InChiKey | MIDKPVLYXNLFGZ-UHFFFAOYSA-N |
| CID | 9926054 |
| Short Description | IKK inhibitor |
References
- JR Burke et al. BMS-345541 is a highly-selective inhibitor of IkB kinase, binds at an Allosteric site of the enzyme, and blocks NF-kB-dependent transcription in mice. J. Biol. Chem. 2003, 278(3), 1450-1456.
- J Yang et al. BMS-345541 Targets Inhibitor of κB Kinase and Induces Apoptosis in Melanoma: Involvement of Nuclear Factor κB and Mitochondria Pathways. Clin. Cancer Res. 2006, 12, 950.
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