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BIX 01294 trihydrochloride
- Soluble in water and DMSO
- MF: C28H38N6O2.3HCl
- MW: 600.02
Description
BIX 01294 trihydrochloride is a G9a/GLP histone lysine methyltransferase inhibitor used to modulate repressive histone methylation marks.
G9a (EHMT2) and GLP (EHMT1) regulate chromatin state and transcription through histone methylation. BIX 01294 is applied in epigenetic studies, stem cell reprogramming and investigation of H3K9/H3K27 methylation-dependent gene regulation.
Key Features
- Inhibits G9a and GLP histone methyltransferases
- Modulates repressive histone methylation pathways
- Used with RG 108 in iPS cell generation studies
- Epigenetic small-molecule tool for chromatin research
Applications
- Histone methylation and chromatin biology
- Stem cell reprogramming research
- Epigenetic gene regulation assays
- Cancer and differentiation pathway studies
Promotion: BIX 01294 is also part of an inhibitor set:
| Stem Cell RG-BIX inhibitor Set (Axon 5008) |
More Information
| Parent CAS No. | 935693-62-2 |
|---|---|
| Chemical Name | N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine trihydrochloride |
| SMILES | C1N(CCN(CC1)C1N=C(C2C=C(OC)C(OC)=CC=2N=1)NC1CCN(CC2C=CC=CC=2)CC1)C.Cl.Cl.Cl |
| MFCD | MFCD11045283 |
| InChi | InChI=1S/C28H38N6O2.3ClH/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-3)25(35-2)18-23(24)27(31-28)29-22-10-14-33(15-11-22)20-21-8-5-4-6-9-21;;;/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31);3*1H |
| InChiKey | FMURUEPQXKJIPS-UHFFFAOYSA-N |
| CID | 46945860 |
| Short Description | HMTase inhibitor |
References
- Y Chang et al. Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat. Struct. Mol. Biol. 2009, 16 312.
- S Kubicek et al. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol. Cell. 2007, 25, 473.
- Y Shi et al. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 2008, 3, 568-574.
- Y Shi et al. A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell. 2008, 2(6), 525-528.
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