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PD173074
- Soluble in DMSO and EtOH
- MF: C28H41N7O3
- MW: 523.67
Description
More Information
| Parent CAS No. | 219580-11-7 |
|---|---|
| Chemical Name | 1-tert-butyl-3-(2-(4-(diethylamino)butylamino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea |
| extra_info | . |
| SMILES | N1=C(N=C2N=C(NC(NC(C)(C)C)=O)C(C3C=C(OC)C=C(OC)C=3)=CC2=C1)NCCCCN(CC)CC |
| MFCD | MFCD08705327 |
| InChi | InChI=1S/C28H41N7O3/c1-8-35(9-2)13-11-10-12-29-26-30-18-20-16-23(19-14-21(37-6)17-22(15-19)38-7)25(31-24(20)32-26)33-27(36)34-28(3,4)5/h14-18H,8-13H2,1-7H3,(H3,29,30,31,32,33,34,36) |
| InChiKey | DXCUKNQANPLTEJ-UHFFFAOYSA-N |
| CID | 1401 |
| Short Description | FGFR inhibitor |
References
- OE Pardo et al. The Fibroblast Growth Factor Receptor Inhibitor PD173074 Blocks Small Cell Lung Cancer Growth In vitro and In vivo. Cancer Res. 2009, 69, 8645.
- M Miyake et al. 1-tert-butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea (PD173074), a selective tyrosine kinase inhibitor of FGFR3 (...). J. Pharmacol. Exp. Ther. 2010, 332 795.
- L Zaragosi et al. Autocrine fibroblast growth factor 2 signaling is critical for self-renewal of human multipotent adipose-derived stem cells. Stem Cells 2006, 24 2412-2419.
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