Aurora A inhibitor I

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1597

CAS [1158838-45-9]

MF C31H31ClFN7O2
MW 588.07

  • Purity: 99%
  • Soluble in DMSO

Aurora A inhibitor I

Description

Potent and selective inhibitor of Aurora A kinase (AurA), with IC50 values to be 3.4 nM (Aurora A) and unusually high selectivity 1000 fold against Aurora B; a useful tool compound for investigating the cellular role of Aurora A kinases.
This ligand has much higher selectivity of Aurora A vs Aurora B than another recently described relatively selective Aurora A inhibitor MLN8054, which shows 43-fold selectivity for Aurora A over Aurora B in enzymatic assays

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5 mg €125.00 In Stock
25 mg €450.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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