TMI 005 - Apratastat

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1507

CAS [287405-51-0]

MF C17H22N2O6S2
MW 414.50

Purity: 99%
Optical purity: >98% ee
Soluble in DMSO

TMI 005

Description

Novel, oral TACE/MMP inhibitor for rheumatoid arthritis; Apratastat (TMI-005) blocks secretion of soluble TNF-α and down regulates multiple MMPs, which have been implicated in cartilage destruction and bone erosions of RA

MM Thabet and TWJ Huizinga. Apratastat, a novel TACE/MMP inhibitor for rheumatoid arthritis. Curr. Opin. Investig. Drugs. 2006, 7(11), 1014-1019.

ML Moss et al. Drug Insight: Tumor Necrosis Factor Converting Enzyme as a Pharmaceutical Target for Rheumatoid Arthritis. Nat. Clin. Pract. Rheumatol. 2008, 4(6), 300.

C Shu et al. Pharmacokinetic-pharmacodynamic modeling of apratastat: a population-based approach. J. Clin. Pharmacol. 2011, 51(4), 472-481.

Apoptosis Cell Signaling & Oncology Immunology Miscellaneous Pain & Inflammation TACE NF-κB EC 3.4.24.86

TACE/MMP inhibitor

Chemical name

(S)-4-[4-(4-Hydroxy-but-2-ynyloxy)-benzenesulfonyl]-2,2-dimethyl-thiomorpholine-3-carboxylic acid hydroxyamide

Parent CAS No.

[287405-51-0]

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5 mg	€150.00	In Stock
25 mg	€570.00	In Stock

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TMI 005 - Apratastat

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