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Axon 1421
CAS [909910-43-6]
MF C25H19N5SMW 421.52
Potent inhibitor of TGF-β type I receptor superfamily activin-like kinase ALK5 and its relatives ALK4 and ALK7 (IC50 to be 12, 45 and 7.5 nM respectively). A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β, but had no effect on BMP signaling; Used to generate rat and human iPS cells towards a mouse ES cell like self-renewal state.
*Note: A 83-01 is found to decompose to A 77-01 (Axon 1744) in solution slowly. Hence freshly prepared solution is highly recommended and otherwise, its stock solution in DMSO needs to be stored <-20 °C (not longer than 1 month).
KEYWORDS: A 83-01 | supplier | ALK5 inhibitor | A83-01 | A8301 | CAS [909910-43-6] | TGF-β | TGF-βR | Antagonist | ALK4 | ALK7 | Smad | signaling | epithelial | mesenchymal | transition | iPS | self-renewal
3-(6-methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide
[909910-43-6]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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