Bulk Inquiry
A 83-01
- Soluble in DMSO
- MF: C25H19N5S
- MW: 421.52
Description
A83-01 is a potent inhibitor of the TGF-β type I receptor superfamily activin-like kinases ALK5, ALK4 and ALK7 with IC50 values of 12 nM, 45 nM and 7.5 nM, respectively. A-83-01 inhibits TGF-β-induced Smad signaling and epithelial-to-mesenchymal transition (EMT) while having no effect on BMP signaling.
The TGF-β/Activin pathway regulates cell differentiation, proliferation, stem cell fate, and tissue homeostasis. A-83-01 is widely used in stem cell research and has been employed to generate rat and human induced pluripotent stem cells (iPSCs) with mouse embryonic stem cell-like self-renewal characteristics. It is also a valuable tool for investigating TGF-β-mediated EMT and cellular reprogramming.
Key Features
- Potent inhibitor of ALK5, ALK4 and ALK7
- IC50: 12 nM (ALK5), 45 nM (ALK4), 7.5 nM (ALK7)
- Blocks TGF-β-induced Smad signaling
- Inhibits epithelial-to-mesenchymal transition (EMT)
- No effect on BMP signaling
Applications
- TGF-β and Activin signaling research
- Stem cell and iPSC generation studies
- Cellular reprogramming investigations
- EMT and fibrosis research
- Smad signaling pathway studies
Note:
A83-01 has been reported to slowly decompose to A77-01 (Axon 1744) in solution. Freshly prepared solutions are recommended. Stock solutions in DMSO should be stored below -20 °C and used within one month.
More Information
| Parent CAS No. | 909910-43-6 |
|---|---|
| Chemical Name | 3-(6-methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide |
| SMILES | C1C=C2C(C3=CN(C(NC4C=CC=CC=4)=S)N=C3C3N=C(C)C=CC=3)=CC=NC2=CC=1 |
| MFCD | MFCD08705403 |
| InChi | InChI=1S/C25H19N5S/c1-17-8-7-13-23(27-17)24-21(19-14-15-26-22-12-6-5-11-20(19)22)16-30(29-24)25(31)28-18-9-3-2-4-10-18/h2-16H,1H3,(H,28,31) |
| InChiKey | HIJMSZGHKQPPJS-UHFFFAOYSA-N |
| CID | 16218924 |
| Short Description | ALK5 inhibitor |
References
- M Tojo et al. The ALK5 inhibitor A-83-01 inhibits smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β. Cancer. Sci. 2005, 96, 791-800.
- W. Li et al. Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell 2009, 4, 16-19.
- List of publications using A 83-01 (Axon 1421) purchased from Axon Medchem
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