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4-Methylhistamine dihydrochloride
- Parent CAS: 36507-31-0
- Soluble in water and DMSO
- MF: C6H11N3.2HCl
- MW: 198.09
Description
4-Methylhistamine dihydrochloride is a potent and selective histamine H4 receptor agonist that exihibits a high binding affinity with a Ki value of 7 nM and >100 fold selectivity for the H4 receptor over other histamine receptor subtypes (H1, H2, H3).
H4 receptors are enriched in immune cells and regulate chemotaxis, cytokine responses, pruritus and inflammatory signaling. 4-Methylhistamine is a useful agonist for studying H4 receptor function in immunopharmacology.
Key Features
- Potent selective H4 receptor agonist
- Activates histamine H4 receptor signaling
- Relevant to immune-cell chemotaxis and inflammation
- Useful for histamine receptor subtype profiling
Applications
- H4 receptor functional assays
- Immune cell migration studies
- Inflammation and pruritus pathway research
- Histamine receptor selectivity studies
More Information
| Parent CAS No. | 36507-31-0 |
|---|---|
| Chemical Name | 2-(5-Methyl-1H-imidazol-4-yl)-ethylamine dihydrochloride |
| SMILES | C1(N=CNC=1C)CCN.Cl.Cl |
| MFCD | MFCD01721796 |
| InChi | InChI=1S/C6H11N3.2ClH/c1-5-6(2-3-7)9-4-8-5;;/h4H,2-3,7H2,1H3,(H,8,9);2*1H |
| InChiKey | BVJIXYJOFWYOBL-UHFFFAOYSA-N |
| CID | 215819 |
| Short Description | H4 agonist |
References
- RK Morgan et al. Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model. J. Immunol. 2007, 178(12), 8081-9.
- Dijkstra, D. et al. Histamine downregulates monocyte CCL2 production through the histamine H4 receptor. J Allergy Clin Immunol. 2007, 120(2), 300-7.
- Lim et al. Evaluation of histamine H1- H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J. Pharmacol. Exp. Ther. 2005, 314, 1310.
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