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Combretastatin-A4
- CA 4
- Soluble in DMSO
- MF: C18H20O5
- MW: 316.35
Description
Combretastatin-A4 is a potent tubulin polymerization inhibitor that disrupts microtubule dynamics and inhibits tumor cell growth.
Combretastatin-A4 binds at the colchicine site of tubulin and is widely studied as a vascular-disrupting and anti-mitotic research compound. It is relevant to cancer pharmacology, angiogenesis and cytoskeletal regulation.
Key Features
- Potent tubulin polymerization inhibitor
- Disrupts microtubule dynamics
- Inhibits tumor cell growth in pharmacological models
- Relevant to vascular-disruption and anti-mitotic research
Applications
- Tubulin polymerization assays
- Cancer cell proliferation studies
- Microtubule dynamics research
- Angiogenesis and vascular disruption models
More Information
| Parent CAS No. | 117048-59-6 |
|---|---|
| Chemical Name | 2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol |
| SMILES | C1(/C=CC2C=C(OC)C(OC)=C(OC)C=2)C=C(O)C(OC)=CC=1 |
| MFCD | MFCD03453309 |
| InChi | InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5- |
| InChiKey | HVXBOLULGPECHP-WAYWQWQTSA-N |
| CID | 5351344 |
| Short Description | Tubuline inhibitor |
References
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