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BMS 303141
- Soluble in DMSO and EtOH
- MF: C19H15Cl2NO4S
- MW: 424.3
Description
Cell-permeable ATP-citrate lyase (ACL) inhibitor (IC50 value 0.13 µM in vitro, and 8 µM for inhibition of total lipid syntheses in HepG2 cells). When administered to mice fed on a high-fat diet, it produced an approximate 20–30% lowering in plasma cholesterol and triglycerides, as well as a 30–50% decrease in fasting plasma glucose, as well as an inhibition of weight gain. BMS 303141 also showed inhibitory effects for other metabolic disease related targets such as ACC1 and ACC2 (IC50 values 6 µM and 12 µM, respectively).
More Information
| Parent CAS No. | 943962-47-8 |
|---|---|
| Chemical Name | 3,5-dichloro-2-hydroxy-N-(4-methoxybiphenyl-3-yl)benzenesulfonamide |
| SMILES | C1(S(NC2C(OC)=CC=C(C3=CC=CC=C3)C=2)(=O)=O)=CC(Cl)=CC(Cl)=C1O |
| MFCD | N.A. |
| InChi | InChI=1S/C19H15Cl2NO4S/c1-26-17-8-7-13(12-5-3-2-4-6-12)9-16(17)22-27(24,25)18-11-14(20)10-15(21)19(18)23/h2-11,22-23H,1H3 |
| InChiKey | SIIPNDKXZOTLEA-UHFFFAOYSA-N |
| CID | 16747776 |
| Short Description | ACL inhibitor |
References
- JJ Li et al. 2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3208-11.
- Z Ma et al. A novel direct homogeneous assay for ATP citrate lyase. J Lipid Res. 2009 Oct;50(10):2131-5.
- A Kinnaird et al. Metabolic control of epigenetics in cancer. Nat Rev Cancer. 2016 Nov;16(11):694-707.
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