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Evacetrapib
- LY 2484595
Axon 2286
CAS:
1186486-62-3
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C31H36F6N6O2
- MW: 638.65
Description
Potent, and selective inhibitor of cholesteryl ester transfer protein (CETP; IC 50 value 5.5 nM and 26 nM in human recombinant and plasme CETP assays, respectively) that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure.
More Information
| Parent CAS No. | 1186486-62-3 |
|---|---|
| Chemical Name | trans-(1S,4r)-4-(((S)-5-((3,5-bis(trifluoromethyl)benzyl)(2-methyl-2H-tetrazol-5-yl)amino)-7,9-dimethyl-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)methyl)cyclohexanecarboxylic acid |
| SMILES | C1(C(F)(F)F)C=C(CN(C2=NN(C)N=N2)[C@]2([H])C3C=C(C)C=C(C)C=3N(C[C@]3([H])CC[C@@]([H])(C(O)=O)CC3)CCC2)C=C(C(F)(F)F)C=1 |&1:15,27,31,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C31H36F6N6O2/c1-18-11-19(2)27-25(12-18)26(5-4-10-42(27)16-20-6-8-22(9-7-20)28(44)45)43(29-38-40-41(3)39-29)17-21-13-23(30(32,33)34)15-24(14-21)31(35,36)37/h11-15,20,22,26H,4-10,16-17H2,1-3H3,(H,44,45)/t20?,22?,26-/m0/s1 |
| InChiKey | IHIUGIVXARLYHP-UXNJHFGPSA-N |
| CID | 49836058 |
| Short Description | CETP inhibitor |
References
- G. Cao et al. Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure. J. Lipid Res. 2011, 52, 2169-2176.
- D.G. Johns et al. On- and off-target pharmacology of torcetrapib: current understanding and implications for the structure activity relationships (SAR), discovery and development of CETP inhibitors. Drugs. 2012, 72, 491-507.
- N.B. Mantlo et al. Update on the discovery and development of cholesteryl ester transfer protein inhibitors for reducing residual cardiovascular risk. J. Med. Chem. 2014, 57, 1-17.
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