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EHop 016
- Soluble in DMSO
- MF: C25H30N6O
- MW: 430.55
Description
EHop 016 is a Rac GTPase inhibitor (IC50 value 1.1 µM) specific for Rac1 and Rac3 at concentrations of 5 µM, and inhibits the interaction of Vav2 with Rac1 at physiologically relevant concentrations. Moreover, EHop-016 inhibits the activation of the Rac downstream effector p21-activated kinase (PAK), extension of motile actin-based structures, and cell migration. EHop-016 is ~100 times more potent than NSC 23766 (Axon 1578) and 10–50 times more potent than other currently available Rac inhibitors.
More Information
| Parent CAS No. | 1380432-32-5 |
|---|---|
| Chemical Name | N4-(9-ethyl-9H-carbazol-3-yl)-N2-(3-morpholinopropyl)pyrimidine-2,4-diamine |
| SMILES | C1(NCCCN2CCOCC2)=NC=CC(NC2=CC3C4=C(N(CC)C=3C=C2)C=CC=C4)=N1 |
| MFCD | N.A. |
| InChi | InChI=1S/C25H30N6O/c1-2-31-22-7-4-3-6-20(22)21-18-19(8-9-23(21)31)28-24-10-12-27-25(29-24)26-11-5-13-30-14-16-32-17-15-30/h3-4,6-10,12,18H,2,5,11,13-17H2,1H3,(H2,26,27,28,29) |
| InChiKey | AFTZZRFCMOAFCR-UHFFFAOYSA-N |
| CID | 51031035 |
| Short Description | Rac inhibitor |
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