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ZCL 278

Axon 2138
CAS:  587841-73-4
Purity:  98%
  • Soluble in DMSO
  • MF:  C21H19BrClN5O4S2
  • MW:  584.89

Description

Selective Cdc42 GTPase inhibitor. ZCL 278 specifically targets Cdc42–ITSN interaction and inhibits Cdc42-mediated cellular processes, thus providing a powerful tool for research of Cdc42 subclass of Rho GTPases in human pathogenesis. ZCL 278 reduces the perinuclear accumulation of active Cdc42 in contrast to NSC 23766 (Axon 1578), a selective Rac inhibitor.

More Information

Parent CAS No. 587841-73-4
Chemical Name 2-(4-bromo-2-chlorophenoxy)-N-(4-(N-(4,6-dimethylpyrimidin-2-yl)sulfamoyl)phenylcarbamothioyl)acetamide
SMILES C(NC(NC1=CC=C(S(NC2=NC(C)=CC(C)=N2)(=O)=O)C=C1)=S)(=O)COC1=CC=C(Br)C=C1Cl
MFCD N.A.
InChi InChI=1S/C21H19BrClN5O4S2/c1-12-9-13(2)25-20(24-12)28-34(30,31)16-6-4-15(5-7-16)26-21(33)27-19(29)11-32-18-8-3-14(22)10-17(18)23/h3-10H,11H2,1-2H3,(H,24,25,28)(H2,26,27,29,33)
InChiKey XKZDWYDHEBCGCG-UHFFFAOYSA-N
CID 1791111
Short Description Cdc42 Inhibitor

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