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CASIN
- Pirl1-related compound 2
Axon 3987
CAS:
425399-05-9
Purity:
99%
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C20H22N2O
- MW: 306.4
Description
CASIN is a selective Cdc42 activity inhibitor. Treatment with CASIN (5µM) reduced the elevated level of active Cdc42 observed in aged primitive hematopoietic cells to the level observed in young cells. CASIN treatment did not alter cell cycle status or apoptosis in aged LT-HSCs. In response to treatment with CASIN, LT-HSCs from aged mice showed a dose-dependent increase in the percentage of polarized cells, becoming progressively indistinguishable from young cells.
More Information
| Parent CAS No. | 425399-05-9 |
|---|---|
| Chemical Name | 2-(6-Phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-ylamino)ethanol |
| SMILES | C1C=C(C2C=C3C4CCCC(NCCO)C=4NC3=CC=2)C=CC=1 |
| MFCD | MFCD01853271 |
| InChi | InChI=1S/C20H22N2O/c23-12-11-21-19-8-4-7-16-17-13-15(14-5-2-1-3-6-14)9-10-18(17)22-20(16)19/h1-3,5-6,9-10,13,19,21-23H,4,7-8,11-12H2 |
| InChiKey | RXIUMAOXORBRCY-UHFFFAOYSA-N |
| CID | 2882155 |
| Short Description | Cdc42 inhibitor |
References
- JR Peterson et al. Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chem Biol. 2006 Apr;13(4):443-52.
- MC Florian et al. Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell. 2012 May 4;10(5):520-30.
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