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MBQ-167
Axon 2777
CAS:
2097938-73-1
Purity:
98%
- Soluble in DMSO
- MF: C22H18N4
- MW: 338.41
Description
MBQ-167 is an effective Rac and Cdc42 inhibitor with IC50 values of 78 nM and 103 nM, respectively. MBQ-167 significantly decreases Rac and Cdc42 downstream effector p21-activated kinase (PAK) signaling and the activity of STAT3, without affecting Rho, MAPK, or Akt activities. MBQ-167 also inhibits breast cancer cell migration, viability, and mammosphere formation.
More Information
| Parent CAS No. | 2097938-73-1 |
|---|---|
| Chemical Name | 9-Ethyl-3-(5-phenyl-1H-1,2,3-triazol-1-yl)-9H-carbazole |
| SMILES | C12C=C(N3N=NC=C3C3C=CC=CC=3)C=CC=1N(CC)C1C=CC=CC2=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C22H18N4/c1-2-25-20-11-7-6-10-18(20)19-14-17(12-13-21(19)25)26-22(15-23-24-26)16-8-4-3-5-9-16/h3-15H,2H2,1H3 |
| InChiKey | LJCANTASZGYJLG-UHFFFAOYSA-N |
| CID | 129896932 |
| Short Description | Rac/Cdc42 inhibitor |
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