Bulk Inquiry
AZ 20
- Optical Purity: Optically pure
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C21H24N4O3S
- MW: 412.51
Description
Potent, orally active and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity (IC50 value 5 nM). AZ 20 potently inhibits the growth of LoVo colorectal adenocarcinoma tumor cells in vitro, and is a useful compound to explore ATR pharmacology in vivo.
More Information
| Parent CAS No. | 1233339-22-4 |
|---|---|
| Chemical Name | (R)-4-(2-(1H-indol-4-yl)-6-(1-(methylsulfonyl)cyclopropyl)pyrimidin-4-yl)-3-methylmorpholine |
| SMILES | N1C2=C(C(C3=NC(C4(S(C)(=O)=O)CC4)=CC(N4CCOC[C@H]4C)=N3)=CC=C2)C=C1 |&1:21,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C21H24N4O3S/c1-14-13-28-11-10-25(14)19-12-18(21(7-8-21)29(2,26)27)23-20(24-19)16-4-3-5-17-15(16)6-9-22-17/h3-6,9,12,14,22H,7-8,10-11,13H2,1-2H3/t14-/m1/s1 |
| InChiKey | SCGCBAAYLFTIJU-CQSZACIVSA-N |
| CID | 46244454 |
| Short Description | ATR inhibitor |
References
- K.M. Foote et al. Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy.... J. Med. Chem. 2013, 56, 2125-2138.
- M.R. Finlay et al. Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family. Bioorg. Med. Chem. Lett. 2012, 22, 5352-5359.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1281 | BEZ 235 |
From $55.00 |
| 1282 | BAG 956 |
From $104.50 |
| 1334 | PIK 75 hydrochloride |
From $77.00 |
| 1362 | PIK 90 |
From $93.50 |
| 1366 | LY 294002 |
From $77.00 |
| 1367 | KU-55933 |
From $121.00 |
| 1377 | GDC 0941 bismesylate |
From $88.00 |
| 1380 | PI 103 hydrochloride |
From $66.00 |
| 1417 | TGX 221 |
From $77.00 |
| 1424 | AS 252424 |
From $93.50 |
| 1436 | AS 252424 bispotassium salt |
From $104.50 |
| 1463 | NU 7441 |
From $44.00 |
| 1495 | CP 466722 |
From $77.00 |
| 1520 | NVP-BBD130 |
From $137.50 |
| 1596 | GSK 2126458 |
From $55.00 |
| 1706 | XL PI3K/mTOR inhibitor |
From $132.00 |
| 1719 | D 106669 |
From $93.50 |
| 1782 | GDC 0980 |
From $88.00 |
| 1797 | NVP-BKM120 |
From $99.00 |
| 1807 | PKI 587 |
From $99.00 |
| 1831 | A 66 |
From $104.50 |
| 1855 | PF 04691502 |
From $99.00 |
| 1893 | VE 821 |
From $88.00 |
| 1912 | GSK 2636771 dihydrochloride |
From $115.50 |
Other Categories
Are you sure you would like to remove this item from the shopping cart?
This item is a part of the approved quote. Removing it will remove all quote items from the cart.