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ADX71743
- Soluble in DMSO
- MF: C17H19NO2
- MW: 269.34
Description
ADX71743 is a selective mGluR7 negative allosteric modulator.
More Information
| Parent CAS No. | N.A. |
|---|---|
| Chemical Name | 6-(2,4-Dimethylphenyl)-2-ethyl-6,7-dihydrobenzo[d]oxazol-4(5H)-one |
| SMILES | C1C=C(C2CC(=O)C3N=C(CC)OC=3C2)C(C)=CC=1C |
| MFCD | MFCD30474715 |
| InChi | InChI=1S/C17H19NO2/c1-4-16-18-17-14(19)8-12(9-15(17)20-16)13-6-5-10(2)7-11(13)3/h5-7,12H,4,8-9H2,1-3H3 |
| InChiKey | CPKZCQHJDFSOJT-UHFFFAOYSA-N |
| CID | 53391766 |
| Short Description | mGLuR7 NAM |
References
- R Klar et al. Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SC-CA1 Synapses in the Hippocampus. J Neurosci. 2015 May 13;35(19):7600-15.
- V Tassin et al. Phasic and Tonic mGlu7 Receptor Activity Modulates the Thalamocortical Network. Front Neural Circuits. 2016 Apr 25;10:31.
- M Kalinichev et al. ADX71743, a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7: in vitro and in vivo characterization. J Pharmacol Exp Ther. 2013 Mar;344(3):624-36.
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