Bulk Inquiry
CHPG
- (RS)-2-Chloro-5-hydroxyphenylglycine - α-Amino-2-chloro-5-hydroxybenzeneacetic acid
- Soluble in DMSO
- MF: C8H8ClNO3
- MW: 201.61
Description
The mGluR5 receptor agonist CHPG selectively activates mGluR5a receptors (EC50 value of 750 μM), compared to mGluR1α receptors, when expressed in CHO cells. CHPG also potentiates NMDA-induced depolarizations in rat hippocampal slices, and is suggested to act directly on mGluR5 in dopaminergic neurons to induce the release of DA. Also CHPG promotes proliferation of human embryonic cortical NSCs with activation of the MAPKs signaling pathway.
More Information
| Parent CAS No. | 170846-74-9 |
|---|---|
| Chemical Name | 2-Amino-2-(2-chloro-5-hydroxyphenyl)acetic acid |
| SMILES | C1(Cl)C(C(N)C(O)=O)=CC(O)=CC=1 |
| MFCD | MFCD01321059 |
| InChi | InChI=1S/C8H8ClNO3/c9-6-2-1-4(11)3-5(6)7(10)8(12)13/h1-3,7,11H,10H2,(H,12,13) |
| InChiKey | UNIDAFCQFPGYJJ-UHFFFAOYSA-N |
| CID | 3645780 |
| Short Description | mGluR5 agonist |
References
- AJ Doherty et al. (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology. 1997 Feb;36(2):265-7.
- L Zhao et al. mGluR5 specific agonist CHPG promotes proliferation of human neural stem cells. Shenjing Jiepouxue Zazhi (2014), 30(1), 7-12.
- C Ferrada et al. The activation of metabotropic glutamate 5 receptors in the rat ventral tegmental area increases dopamine extracellular levels. Neuroreport. 2017 Jan 1;28(1):28-34.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1222 | MPEP hydrochloride |
From $82.50 |
| 1224 | (±)-LY 367385 |
From $93.50 |
| 1259 | Desmethyl YM 298198 hydrochloride |
From $154.00 |
| 1260 | YM 298198 hydrochloride |
From $121.00 |
| 1345 | Fenobam |
From $77.00 |
| 1425 | VU 29 |
From $110.00 |
| 1431 | CPPHA |
From $104.50 |
| 1739 | (RS)-3,5-DHPG |
From $99.00 |
| 1740 | (S)-3,5-DHPG |
From $99.00 |
| 1795 | VU 0360223 |
From $126.50 |
| 1894 | VU 0357121 |
From $93.50 |
| 1972 | CTEP |
From $132.00 |
| 2155 | A 841720 |
From $93.50 |
| 2732 | ADX71743 |
From $132.00 |
| 3421 | VU0360172 hydrochloride |
From $104.50 |
