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Clioquinol
- Soluble in 0.1N NaOH(aq), DMSO and EtOH
- MF: C9H5ClINO
- MW: 305.5
Description
Clioquinol is a MMP14/CLK-1 inhibitor and a metal chelator.
More Information
| Parent CAS No. | 130-26-7 |
|---|---|
| Chemical Name | 5-Chloro-7-iodoquinolin-8-ol |
| SMILES | C1C(Cl)=C2C=CC=NC2=C(O)C=1I |
| MFCD | MFCD00006787 |
| InChi | InChI=1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H |
| InChiKey | QCDFBFJGMNKBDO-UHFFFAOYSA-N |
| CID | 2788 |
| Short Description | MMP14/CLK-1 inhibitor |
References
- Y Wang et al. The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1. J Biol Chem. 2009 Jan 2;284(1):314-323.
- H Lee et al. Identification of small molecule inhibitors against MMP-14 via High-Throughput screening. Bioorg Med Chem. 2023 Apr 17;85:117289.
- SR Bareggi et al. Clioquinol: review of its mechanisms of action and clinical uses in neurodegenerative disorders. CNS Neurosci Ther. 2012 Jan;18(1):41-6.
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