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Ilomastat
- GM6001
- Optical Purity: Optically pure
- Soluble in DMSO and EtOH
- MF: C20H28N4O4
- MW: 388.46
Description
Ilomastat (GM6001) is a potent, cell permeable matrix metalloproteinase (MMP) inhibitor with IC50 values of 1.5 nM, 1.1 nM, 1.9 nM and 0.5 nM for MMP-1, MMP-2, MMP-3 and MMP-9 respectively. Moreover, Ilomastat inhibits human skin fibroblast collagenase (MMP-1) with a Ki value of 0.4 nM. Ilomastat is considered a broad-spectrum MMP inhibitor because it potently inhibits a wide range of zinc-dependent MMP enzymes simultaneously, rather than targeting just one specific type.
More Information
| Parent CAS No. | 142880-36-2 |
|---|---|
| Chemical Name | N-((S)-2-(3-Indolyl)-1-(N-methylcarbamoyl)ethyl)(R)-2-(hydroxamomethyl)-4-methylvaleramide |
| SMILES | ONC(=O)C[C@@H](CC(C)C)C(=O)N[C@@H](CC1C2=CC=CC=C2NC=1)C(=O)NC |&1:5,13,r| |
| MFCD | MFCD00917040 |
| InChi | InChI=1/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/s3 |
| InChiKey | NITYDPDXAAFEIT-BLYWGVECNA-N |
| CID | 132519 |
| Short Description | MMP inhibitor |
References
- D Grobelny et al. Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry. 1992 Aug 11;31(31):7152-4.
- M Yamamoto et al. Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocket. J Med Chem. 1998 Apr 9;41(8):1209-17.
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