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Axon 2474
CAS [1465248-60-5]
MF C27H22N2O5MW 454.47
Orally active inhibitor of transforming acidic coiled-coil protein (TACC3) that selectively inhibits the nucleation of centrosome microtubules in ovarian cancer cells, without affecting spindle assembly in normal cells. SPL significantly inhibits mitosis in cancer cells and suppresses in vivo tumor growth.
KEYWORDS: SPL-B | supplier | TACC3 inhibitor | Spindlactone B | SPLB | CAS [1465248-60-5] | microtubules | MTs | TACC | Inhibitor | proteins | mitotic spindle | assembly | mitosis | centrosomal | TOGp | Aurora A | coumarin | cell-cycle regulation | differentiation
8'-((ethyl(pyridin-4-ylmethyl)amino)methyl)-7'-hydroxy-2H,2'H-3,4'-bichromene-2,2'-dione
[1465248-60-5]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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